Preparation of (S)-piperazine-2-carboxylic acid,(R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid by kinetic resolution of the corresponding …

E Eichhorn, JP Roduit, N Shaw, K Heinzmann…

Index: Eichhorn, Eric; Roduit, Jean-Paul; Shaw, Nicholas; Heinzmann, Klaus; Kiener, Andreas Tetrahedron Asymmetry, 1997 , vol. 8, # 15 p. 2533 - 2536

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Citation Number: 65

Abstract

Whole bacterial cells containing stereospecific amidases were used for the kinetic resolution of racemic piperazine-2-carboxamide and piperidine-2-carboxamide to (S)-and (R)- piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid, respectively.(S)- Piperazinecarboxylic acid dihydrochloride produced with the biocatalysts Klebsiella terrigena DSM 9174 had an ee value of 99.4%(41% yield), and the ee value of (R)- ...