Tetrahedron

Synthesis of 2′, 3′-dideoxy-3′, 3′-difluoro and 2′, 3′-dideoxy-2′, 2′-difluoro-pyranosyl nucleosides analogues of gemcitabine

R Fernández, S Castillón

Index: Fernandez, Raul; Castillon, Sergio Tetrahedron, 1999 , vol. 55, # 28 p. 8497 - 8508

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Citation Number: 23

Abstract

The gem-difluoronucleosides 1 and 2, pyranosyl analogues of gemcitabine, have been synthesized from d-mannose and d-glucose respectively. The key steps were the formation of the difluoromethylene group by reaction of the corresponding ulose with DAST, and the glycosylation.