Synthesis of gem??Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source

…, SK Ganesh, GK Prakash, GA Olah

Index: Wang, Fei; Luo, Tao; Hu, Jinbo; Wang, Ying; Krishnan, Hema S.; Jog, Parag V.; Ganesh, Somesh K.; Prakash, G. K. Surya; Olah, George A. Angewandte Chemie - International Edition, 2011 , vol. 50, # 31 p. 7153 - 7157

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Citation Number: 95

Abstract

Difluorocyclopropanes and difluorocyclopropenes are becoming an important class of compounds in organofluorine chemistry. Introduction of a fluorine atom onto a cyclopropane ring is known to alter the structure and reactivity of the molecule because of the high electronegativity and small size of the fluorine atom, and consequently the increase in the CÀF bond polarity.[1] Fluorine substituents also raise the biological activity, the ...