Novel 5-substituted 2, 4-thiazolidinedione and 2, 4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities

…, T Yamano, M Kawada, H Odaka, H Ikeda…

Index: Momose, Yu; Maekawa, Tsuyoshi; Yamano, Tohru; Kawada, Mitsuru; Odaka, Hiroyuki; Ikeda, Hitoshi; Sohda, Takashi Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1518 - 1534

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Citation Number: 93

Abstract

Two novel classes of 2, 4-thiazolidinediones and 2, 4-oxazolidinediones with an ω- (azolylalkoxyphenyl) alkyl substituent at the 5-position were prepared and their antidiabetic effects were evaluated in two genetically obese and diabetic animal models, KKAy mice and Wistar fatty rats. A large number of the 2, 4-thia (oxa) zolidinediones showed potent glucose- and lipid-lowering activities. The antidiabetic activities of the 2, 4-oxazolidinediones were ...