Tetrahedron Letters

Boron-mediated aldol reactions of ethyl α-(N, N)-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity

I Paterson, AC Mackay

Index: Paterson, Ian; Mackay, Angela C. Tetrahedron Letters, 2001 , vol. 42, # 52 p. 9269 - 9272

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Citation Number: 7

Abstract

The boron-mediated aldol reactions of a range of chiral α-(N, N)-dibenzylamino ketones with aldehydes can be controlled to provide stereodefined adducts. Complementary induction can be achieved with cHex2BCl/Me2NEt leading to preferential formation of the 1, 2-anti-2, 4-