… Mediated Phenomena. 19. Synthesis of (+)-4-[(. alpha. R)-. alpha.-((2S, 5R)-4-Allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethylbenzamide (SNC 80): A …

…, F Porreca, JL Flippen-Anderson…

Index: Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128

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Citation Number: 229

Abstract

(*)-1 (BW373U86) 46.3* 4.42 0.92* 0.06 50.3 (-)-l (as,! 2R, 55) 2322 199 9.58 0.85 242 (+)-l (d, 2S, 5R) 9.71 f 0.37 0.31 f 0.02 31 (-)-8 (aS, 2R, 5S) 9366 798> 2000 nd (+)-8 (aR, 2S, 5R) 2467 f 200 1-06 f 0.14 2327 (-)-9 (d92R, 5S) 9138 823 3.50 0.39 2611 (-)-lo (aR, 2R95S) 167 42 0.49 0.07 341 (+)-lo (aS, 2S, 5R) 426 f 53 5.96 f 0.53 71 a Binding against [SHIDAMGO in rat brain membranes. s* Binding against [SHIDADLES in mouse brain ...