Preparation of polysubstituted piperidines via radical cyclization

AR Katritzky, Z Luo, Y Fang, D Feng…

Index: Katritzky, Alan R.; Luo, Zhushou; Fang, Yunfeng; Feng, Daming; Ghiviriga, Ion Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 7 p. 1375 - 1380

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Citation Number: 14

Abstract

Molander et al. prepared six-membered carbocyclic and some heterocyclic rings by radical cyclization of phenyl or ketyl-olefin radicals to unactivated double bonds promoted by samarium diiodide. 6a–c However, no nitrogen six-membered heterocycles were reported by this method. Parsons and Pettifer demonstrated that substituted pyrrolidines and piperidines could be formed using tin hydride-mediated cyclization of a variety of α- and β-homoallylamino ...