Abstract New methods for the preparation of irbesartan 1 have been described. The dehydration and tetrazole formation in one step from substituted cyclopentane derivative 7 with tributyltin chloride and sodium azide is described. Selective hydrolysis of nitrile 3 with HCl has also been described in the preparation of N??acylaminocyclopentane??2??carboxylic acid 4, which is the key intermediate for the preparation of irbesartan. The impurity ...
![N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-1-[(1-oxopentyl)amino]cyclopentanecarboxamide Structure](https://image.chemsrc.com/caspic/247/141745-71-3.png)