The substrate specificity of cytochrome P450 cam

…, O Sibbesen, RA Johnson, PRO de Montellano

Index: Zhang, Zhoupeng; Sibbesen, Ole; Johnson, Roy A.; Ortiz De Montellano, Paul R. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1501 - 1508

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Citation Number: 25

Abstract

The catalytic turnover of xenobiotics by cytochrome P450cam results in both the formation of organic metabolites and the uncoupled production of H2O2, and H2O. Previous studies have shown that a receptor-constrained three-dimensional screening program (DOCK) can be used to identify potential ligands (ergo substrates) for the enzyme (De Voss, JJ; Sibbesen, O.; Zhang, Z.; Ortiz de Montellano, PRJ Am. Chem. Soc. 1997, 119, 5489). A ...