Synthetic Communications

Simple and efficient synthesis of (S)-dapoxetine

M Sasikumar, MD Nikalje

Index: Sasikumar; Nikalje, Milind D. Synthetic Communications, 2012 , vol. 42, # 20 p. 3061 - 3067

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Citation Number: 4

Abstract

A refinement in the synthetic strategy for (S)-dapoxetine 1 is described. The key features of synthetic strategy include (a) a Sharpless asymmetric epoxidation reaction and regioselective reductive ring opening of a 2,3-epoxy alcohol to elaborate the hydroxy-bearing stereogenic center ...

~90%

Asymmetric total synthesis of (S)-dapoxetine

[Kim, Sun Joo; Jeon, Tae Hong; Min, Im Sook; Kim, In Su; Jung, Young Hoon Tetrahedron Letters, 2012 , vol. 53, # 28 p. 3680 - 3682]