Structure

Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification

S Jansen, A Perrakis, C Ulens, C Winkler, M Andries…

Index: Jansen, Silvia; Perrakis, Anastassis; Ulens, Chris; Winkler, Claudia; Andries, Maria; Joosten, Robbie P.; Van Acker, Maarten; Luyten, Frank P.; Moolenaar, Wouter H.; Bollen, Mathieu Structure, 2012 , vol. 20, # 11 p. 1948 - 1959

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Citation Number: 21

Abstract

Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) converts extracellular nucleotides into inorganic pyrophosphate, whereas its close relative NPP2/autotaxin hydrolyzes lysophospholipids. NPP1 regulates calcification in mineralization-competent tissues, and a lack of NPP1 function underlies calcification disorders. Here, we show that NPP1 forms homodimers via intramembrane disulfide bonding, but is also processed ...

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