It was therefore interesting to carry out a comprehensive study of the biological properties of 2, 4-dioxo-3H-quinoline-3-carboxylic acid and its ethyl ester, which, being direct analogs of the 3-substituted 4-hydroxyquinol-2-ones widely distributed in nature [6], have regrettably remained virtually unstudied from the pharmacological viewpoint up to the present time. we obtained 3-carbethoxy-4-hydroxy-2-quinolone (II) by the intramolecular cyclization of ethyl ...
