New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2′ region

MS Malamas, J Erdei, I Gunawan, K Barnes…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5164 - 5170

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Citation Number: 13

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Currently, the approved medical therapies consist of cholinesterase inhibitors and N-methyl d-aspartate (NMDA) antagonists, that reduce the symptomatology of the disease in the initial phase, but do not appear to be capable of ...