Conversion of 1??methyl??4??phenyl??1, 2, 3, 6??tetrahydropyridine (mptp) and its 5??methyl analog into pyridinium salts

W Gessner, A Brossi, RS Shen, RR Fritz…

Index: Gessner, Wieslaw; Brossi, Arnold; Shen, Rong-sen; Fritz, Richard R.; Abell, Creed W. Helvetica Chimica Acta, 1984 , vol. 67, p. 2037 - 2042

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Citation Number: 35

Abstract

Abstract Monoamine oxidase B metabolizes 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP; 1) first to 1-methyl-4-phenyl-2, 3-dihydropyridinium salt (MPDP+; 5), and then to 1- methyl-4-phenylphridinium salt (MPP+; 7). Chemical synthesis of MPDP+ and its 5-methyl ...