6-Methyl-and 1, 6-dimethyl-4-aryl-5-nitro-2-oxo-1, 2, 3, 4-tetrahydropyrimidines: Modulators of calcium influx

GY Remennikov, SS Shavaran, IV Boldyrev…

Index: Remennikov, G. Ya.; Shavaran, S. S.; Boldyrev, I. V.; Kapran, N. A.; Kurilenko, L. K.; et al. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 5 p. 322 - 326 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 5 p. 25 - 29

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Citation Number: 6

Abstract

With the aim of increasing the number of potential calcium modulators, we have synthesized new derivatives or omethyl-and 1, 6-dimethyl-4-aryl-5-nitro-2-oxo-1, 2, 3, 4- tetrahydropyrimidines, in which the phenyl fragment contains substituents with different electronic properties, and we have studied their pharmacological properties. In addition, we have studied new approaches to the synthesis of these compounds.