Synlett

Application of the catalytic Friedel-Crafts acylation reaction and regioselectivity correlations

MC Wilkinson, F Saez, WLE Hon

Index: Wilkinson, Mark C.; Saez, Fabienne; Wei, Lee Hon Synlett, 2006 , # 7 p. 1063 - 1066

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Citation Number: 12

Abstract

Abstract A correlation was found between electronic properties and regioselectivity in the Friedel-Crafts reaction of substituted phenylacetic and benzoic acids with anisole, utilising substoichiometric (down to 1 mol%) amounts of catalyst. Relative reactivities of selected catalysts for this reaction were also studied.

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