The quinolones prepared for this study were tested against 10 representative Gram-negative and Gram-positive organisms by using standard microtitration technique~.~~ The minimum inhibitory concentrations (MICs, in pg/mL) are presented in Table 111. In order to facilitate comparisons in activity between compounds, the geometric means of the MICs were calculated for both Gram-positive and Gram-negative strains and are included in Tables IV ...
