Tetrahedron Letters

Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine

T Mo, X Mi, EE Milner, GS Dow, P Wipf

Index: Mo, Tingting; Mi, Xueling; Milner, Erin E.; Dow, Geoffrey S.; Wipf, Peter Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5137 - 5140

Full Text: HTML

Citation Number: 34

Abstract

The geographic extension of Plasmodium falciparum necessitates the development of new antimalarial drugs that are active against resistant parasite strains. 1 Mefloquine (1) has been shown to have high efficacy for both treatment and prophylaxis of chloroquine-resistant malaria (Fig. 1). 2 However, its present potential is limited due to its adverse central nervous system (CNS) effects, including anxiety, depression, hallucinations, and seizures. 3 One explanation for ...