Abstract The alkylation of 2-amino-6-nitro-and 2, 6-diaminobenzothiazoles by ethylene chlorohydrin has been studied. A comparative analysis has been made of the composition of these reaction mixtures and of those obtained from other 2-aminobenzothiazoles using this reaction. The structure of the synthesized compounds was confirmed using IR and 1 H NMR spectroscopy, mass spectrometry, and X-ray diffraction and via alternative syntheses.