Chemistry Letters

Thermoresponsive polyphosphoesters bearing enzyme-cleavable side chains

Y Iwasaki, T Kawakita, S Yusa

Index: Iwasaki, Yasuhiko; Kawakita, Takashi; Yusa, Shin-Ichi Chemistry Letters, 2009 , vol. 38, # 11 p. 1054 - 1055

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Citation Number: 16

Abstract

Thermoresponsive polyphosphoesters bearing acetoxymethyl (AM) groups were newly synthesized. The polymers had the LCST-type cloud point in aqueous media, and the thermoresponsive phenomena was influenced by the condition of the medium. About 40% of the AM groups in the polymers were cleaved in contact with esterase for 24 h in phosphate buffer solution. This was significant compared with the spontaneous cleavage in the buffer ...