Enantioselective synthesis of protected cyanohydrins

…, S Telalovic, U Hanefeld, T Maschmeyer

Index: Veum, Lars; Kuster, Marina; Telalovic, Selvedin; Hanefeld, Ulf; Maschmeyer, Thomas European Journal of Organic Chemistry, 2002 , # 9 p. 1516 - 1522

Full Text: HTML

Citation Number: 22

Abstract

Abstract A straightforward process for the preparation of optically active protected cyanohydrins, important building blocks for the synthesis of drugs and agrochemicals, has been established. Lipase B from Candida Antarctica (CAL-B) catalysed the kinetic resolution of racemic cyanohydrin acetates under mild conditions. The resulting labile cyanohydrins were reprotected either by an enzyme-catalysed route involving the addition of vinyl ...