Hybrid molecules: Growth inhibition of leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-. beta.-carbolines

…, C Ouannes, M Robert-Gero, P Potier

Index: Dodd; Ouannes; Robert-Gero; Potier Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1272 - 1276

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Citation Number: 44

Abstract

The thiosemicarbazones of@-carboline-3-carboxaldehyde (compound 2) and 3-acetyl-@- carboline (compound 3) were found to effectively inhibit the in vitro growth of the promastigote form of Leishmania donovani, 50% inhibition being obtained at concentrations of 5.0 and 2.5 pM, respectively, while irreversible growth inhibition was achieved at 40 (compound 2) and 17.5 pM (compound 3). The thiosemicarbazone of pyridine-2- ...