Synthesis and antibacterial activity of certain N-acyl-N', N'-di (2-chloroethyl)-N"-(1-oxyl-2, 2, 6, 6-tetramethylpiperidyl-4)-triamides of phosphoric acid

LD Protsenko, IA Avrutskaya, TN Dneprova…

Index: Protsenko, L. D.; Avrutskaya, I. A.; Dneprova, T. N.; Kodintseva, E. Yu.; Andrianova, S. M.; Sologub, P. Ya. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 7 p. 527 - 529 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 7 p. 803 - 805

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Abstract

With that purpose in mind we synthesized N-acyl-N'-N'-di (2-chloroethyl)-N"-(l-oxyl-2, 2, 6, 6- tetramethylpiperidyl-4) triamides of phosphoric acid (IIa-c) by consecutively reacting the dichloroanhydrides of appropriate N-acylamidophosphoric acids (I) first with a rigidly computed quantity of di (2-chloroethyl) amine in the presence of EtsN, and then with the free radical l-oxyl-2, 2, 6, 6-tetramethyl-4-aminopiperidine in the presence of Et3N in a mixture ...