Synthetic communications

Efficient Synthesis of (±)??Juglomycin A

JP Min, JC Kim, OS Park

Index: Min, Jong-Pil; Kim, Ju-Cheun; Park, Oee-Sook Synthetic Communications, 2004 , vol. 34, # 3 p. 383 - 390

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Citation Number: 6

Abstract

Scheme 1. (i) Paraformaldehyde, MgCl 2 , Et 3 N, CH 3 CN, reflux, 15h; (ii) NaCN, AcOH; THF, 0–5°C, 3h; (iii) CH 2 ˭CHOCH 2 CH 3 , p??TsOH; rt, 0.5h; (iv) LDA, CH 3 OCH˭CHCO 2 CH 3 , THF, −78°C, 1h, 10% H 2 SO 4 , rt, 0.5h (v) L-selectride; THF, −78°C, 1.5h; (vi) Phl(OAc) 2 , CH 3 CN??H 2 O, rt, 1h; (vii) CF 3 CO 2 H; CH 2 Cl 2 , 0°C 7h; (viii) BCl 3 /n??Bu 4 NI, CH 2 Cl 2 , −78°C → −20°C, 0.5h. ... Scheme 1. (i) Paraformaldehyde, MgCl 2 , Et 3 N, ...