New 7??substituted quinolone antibacterial agents. The synthesis of 1??ethyl??1, 4??dihydro??4??oxo??7??(2??thiazolyl and 4??thiazolyl)??3??quinolinecarboxylic acids

…, JM Domagala, P Peterson, S Bongers…

Index: Culbertson; Domagala; Peterson; Bongers; Nichols Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1509 - 1520

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Citation Number: 20

Abstract

Abstract A series of 1-ethyl-1, 4-dihydro-4-oxo-7-(4-thiazolyl)-3-quinolinecarboxylic acids and 1-ethyl-1, 4-dihydro-4-oxo-7-(2-thiazolyl)-3-quinolinecarboxylic acids were prepared. Also prepared was 10-[2-(aminomethyl)-4-thiazolyl]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H- pyrido [1, 2, 3-de][1, 4] benzoxazine-6-carboxylic acid. Analogs with basic amine substituents on the thiazole moiety were found to have antibacterial activity.