e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Structure–activity relationships for vitamin D3-based aromatic A-ring analogues as Hedgehog pathway inhibitors
AM DeBerardinis, DJ Madden, U Banerjee…
Index: Deberardinis, Albert M.; Madden, Daniel J.; Banerjee, Upasana; Sail, Vibhavari; Raccuia, Daniel S.; De Carlo, Daniel; Lemieux, Steven M.; Meares, Adam; Hadden, M. Kyle Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3724 - 3736
A structure–activity relationship study for a series of vitamin D3-based (VD3) analogues that incorporate aromatic A-ring mimics with varying functionality has provided key insight into scaffold features that result in potent, selective Hedgehog (Hh) pathway inhibition. Three analogue subclasses containing (1) a single substitution at the ortho or para position of the aromatic A-ring,(2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the ...
