Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones

…, M Tomita, K Fuhshuku, R Obata, S Nishiyama…

Index: Hiraoka, Chihiro; Matsuda, Masaaki; Suzuki, Yuya; Fujieda, Shigeo; Tomita, Mina; Fuhshuku, Ken-ichi; Obata, Rika; Nishiyama, Shigeru; Sugai, Takeshi Tetrahedron Asymmetry, 2006 , vol. 17, # 24 p. 3358 - 3367

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Citation Number: 16

Abstract

Towards the synthesis of sterically hindered optically active secondary alcohol 2, yeast strains (Candida floricola IAM 13115 and Trichosporon cutaneum IAM 12206) with si-face hydride attack on isopropyl phenylsulfonylmethyl ketone 1 were developed by screening. Strains with complementary re-facial selectivity (Pichia angusta IAM 12895 and Pichia minuta IAM 12215) were also found. Based on the substrate specificity studies of these ...