Synthesis of chlorophyll–amino acid conjugates as models for modification of proteins with chromo/fluorophores

H Tamiaki, Y Isoda, T Tanaka, S Machida

Index: Tamiaki, Hitoshi; Isoda, Yasuaki; Tanaka, Takuya; Machida, Shinnosuke Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1421 - 1428

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Citation Number: 4

Abstract

Abstract A chlorophyll-a derivative bonded directly with epoxide at the peripheral position of the chlorin π-system was reacted with N-urethane and C-ester protected amino acids bearing an alcoholic or phenolic hydroxy group as well as a carboxy group at the residue to give chlorophyll–amino acid conjugates. The carboxy residues of N, C-protected aspartic and glutamic acids were esterified with the epoxide in high yields. The synthetic ...