Chemistry and anti-HIV properties of 2'-fluoro-2', 3'-dideoxyarabinofuranosylpyrimidines

…, T Shirasaka, H Mitsuya, JJ Barchi Jr…

Index: Siddiqui; Driscoll; Marquez; Roth; Shirasaka; Mitsuya; Barchi Jr.; Kelley Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2195 - 2201

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Citation Number: 32

Abstract

Table I. Octanol-Water Partition Coefficients and Chromatographic Properties of Some 2', 3'- Dideoxy Pyrimidine Nucleosides and Related ComDounds partition coefficients HPLC mobile compound logp phase* B-Cl-O'-F-dd-ara-U (7c)-0.28 t 0.01 E bMe-P'-F-dd-ara-U (7d)- 0.44* 0.01 E bC1-2'-F-dd-ara-C (1 1)-0.46 t 0.02 F 5, 2'-Fz-dd-ara-U (7b)-0.72 t 0.01 C 2'-F- dd-ara-U (78)-0.87 0.00 C 5, 2'-Fz-dd-ara-C (lob)-0.92 t 0.02 F ddU-1.00 f 0.01 c