Synthesis and antiinflammatory activity of 1-[2, 6-D-dichlorophenyl] indolin-2-ones

GS Predvoditeleva, TV Kartseva, ON Oleshko…

Index: Predvoditeleva, G. S.; Kartseva, T. V.; Oleshko, O. N.; Shvedov, V. I.; Syubaev, R. D.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 4 p. 275 - 278 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 4 p. 441 - 445

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Abstract

On heating (II) with caustic alkali in aqueous alcohol, cleavage of the dimethylaminogroup takes place with the formation of the sodium salt (III). Boiling (II) with hydroxylamine hydrochlorlde in the presence of pyridine also results in cleavage of the dimethyl.. amino- group, but in this case the dioxime of the corresponding diformyl derivative (IV) is obtained. Reaction of (II) with malonodinitrile at the boil for ih in aleohol in the presence of ...