Deoxyribose 5-phosphate aldolase as a catalyst in asymmetric aldol condensation

L Chen, DP Dumas, CH Wong

Index: Chen, Lihren; Dumas, David P.; Wong, Chi-Huey Journal of the American Chemical Society, 1992 , vol. 114, # 2 p. 741 - 748

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Citation Number: 93

Abstract

Abstract: This paper describes the substrate specificity and synthetic utility of deoxyribose-5- phosphate aldolase (DERA, EC 4.1. 2.4). Eight donors and 20 acceptors have been tested as substrates. In addition to acetaldehyde, propanal, acetone, and fluoroacetone have been used to condense with a number of acceptor aldehydes. Thirteen aldol products have been prepared and characterized. A new stereogenic center with 3 (S) configuration is formed ...