Synthesis and antiarrhythmic activity of new [(dialkylamino) alkyl] pyridylacetamides

…, C Condamine, H Demarne, R Roncucci…

Index: Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455

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Citation Number: 28

Abstract

The synthesis of new [(dialkylamino) alkyl] pyridylacetamides is reported. These compounds displayed a potent antiarrhythmic activity, as demonstrated on a model of myocardial infarction in the conscious dog. Structure-activity relationships are discussed within a series of 22 homologues, comparing relative antiarrhythmic properties and cardiac side effects. One of these compounds, 15, has been selected as a candidate for clinical evaluation in ...