Department of Agricultural Chemistry, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan ... An enantioselective synthesis of patulolide A (1). patulolide B (2). and pdtulolide C (3) from ethyl (R)-3-bydroxybutanoate is de- scribed. ... Recently Yamada and his co-workers isolated three new antimicrobial macrolides from the culture broth of Penicil- lium urticae mutant S11R59, named them patulolide A, B, and C and clarified their structures as depicted in ...