Organic letters

Expedient approach to chiral cyclobutanones: asymmetric synthesis of cyclobut-G

B Darses, AE Greene, SC Coote, JF Poisson

Index: Darses, Benjamin; Greene, Andrew E.; Coote, Susannah C.; Poisson, Jean-Francois Organic Letters, 2008 , vol. 10, # 5 p. 821 - 824

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Citation Number: 25

Abstract

An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl-and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.