Highly stereoselective reduction of haloketones using three new yeasts: application to the synthesis of (S)-adrenergic β-blockers related to propranolol

FM Lagos, JD Carballeira, JL Bermudez, E Alvarez…

Index: Martinez Lagos, Fernando; Carballeira, Jose D.; Bermudez, Jose L.; Alvarez, Emilio; Sinisterra, Jose V. Tetrahedron Asymmetry, 2004 , vol. 15, # 5 p. 763 - 770

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Citation Number: 33

Abstract

The stereoselective reduction of aryloxy-halo-2-propanones or of 1-chloro-3 (phthalimdyl)- propan-2-one using baker's yeast usually displays poor yields and/or ees. Three new yeasts, Saccharomyces bayanus CECT 1317, Yarrowia lipolytica CECT 1240 and Pichia mexicana CECT 1015, were selected after a taxonomical screening looking for microorganisms active in the reduction of ketones. These strains have been used for the ...