Tetrahedron letters

New observations on peptide bond formation using CDMT

CE Garrett, X Jiang, K Prasad, O Repič

Index: Garrett, Christine E.; Jiang, Xinglong; Prasad, Kapa; Repic, Oljan Tetrahedron Letters, 2002 , vol. 43, # 23 p. 4161 - 4165

Full Text: HTML

Citation Number: 37

Abstract

The optimized formation of the peptide bond by means of 2-chloro-4, 6-dimethoxy-1, 3, 5- triazine (CDMT) has been found to occur rapidly and essentially quantitatively in a one-pot, one-step procedure. This new method is effective for the coupling of a variety of reactive partners, including chiral amino acids (eg N-acetyl-l-leucine) without significant loss of configuration. Significant racemization was observed when the typical literature conditions ...