Transsialidase from Trypanosoma cruzi for Regio??and Stereoselective Synthesis of N??Acyl??Modified Sialylated Oligosaccharides and Measurement of Transfer Rates

A Schroven, S Meinke, P Ziegelmüller…

Index: Schroven, Andreas; Meinke, Sebastian; Ziegelmueller, Patrick; Thiem, Joachim Chemistry - A European Journal, 2007 , vol. 13, # 32 p. 9012 - 9021

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Citation Number: 22

Abstract

Abstract Recombinant transsialidase from Trypanosoma cruzi (TcTS) was used for the sialylation with natural and non-natural derivatives of neuraminic acid. Neu5Ac-α (2→ 3)-Gal- β (1→ 6)-Glc-αOMe was prepared in 80% yield. Correspondingly, the modified trisaccharide derivatives Neu5Prop-α (2→ 3)-Gal-β (1→ 6)-Glc-αOMe (32%) and Neu5Gc-α (2→ 3)-Gal-β (1→ 6)-Glc-αOMe (Prop= propanoyl, Gc= glycolyl) were obtained in 60% yield, ...