Synthesis and pharmacological examination of some (6-dialkylaminopyrimidin-4-ylthio) acetic acids

…, SP Tumkyavichyus, AA Denene, VSM Rochka…

Index: Vainilabichus, P. I.; Tumkyavichyus, S. P.; Denene, A. A.; Rochka, V.-S. M.; Lautsyuvene, I. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 11 p. 775 - 779 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 11 p. 1335 - 1339

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Abstract

Np_H 4.} i~ N~'(C1 {3) 2GO ac z ac~ 7 ac R's-(cn) zs~ b-morpholAno i c-piperidtno excesa in the reaction mixture, and reducing the reaction temperature favored the formation of (II). Thus, at 0~ we were able to obtain (II) almost exclusively. The structures of (II) and (III) were confirmed by their elemental analyses (Table i) and~ H NMR spectra (Table 2), which showed that both compounds contained protons of the same type. The intensities of the ...