Synthesis of N-Fmoc-4-[(diethylphosphono)-2′, 2′-difluoro-1′-hydroxyethyl] phenylalanine, a novel phosphotyrosyl mimic for the preparation of signal transduction …

S Chetyrkina, K Estieu-Gionnet, G Laı̈n, M Bayle…

Index: Chetyrkina, Svitlana; Estieu-Gionnet, Karine; Lain, Georges; Bayle, Mireille; Deleris, Gerard Tetrahedron Letters, 2000 , vol. 41, # 12 p. 1923 - 1926

Full Text: HTML

Citation Number: 8

Abstract

We underwent the synthesis of non-hydrolyzable analogues of phosphotyrosine incorporating both of these structural moieties, of which the influence on the binding to the catalytic site was very recently illustrated. We present here our preliminary results dealing with the synthesis of derivatives of 4-[(diethylphosphono)-2′,2′-difluoro-1′-hydroxyethyl]-dl-phenylalanine. Beside the synthesis of this original compound, we illustrated our synthetic scheme with a new ...