Tetrahedron letters

Partial synthesis of germacranolides with pyran and furan-type rings

AS Hernández, MM Afonso, AG Gonzalez, A Galindo

Index: Hernandez; Afonso; Gonzalez; Galindo Tetrahedron Letters, 1992 , vol. 33, # 33 p. 4747 - 4750

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Citation Number: 9

Abstract

Abstract Pathways to synthesize germacranolides with ether bridges between C 1 and C 5 or C 3 and C 10 were described. A joint precursor was prepared using a readily available and inexpensive compound as starting material. The key step in the preparation of dihydropyranone-germacranolides proved to be a one-pot procedure involving several transformations, induced by the iodotrimethylsilane/acetonitrile system.