Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii

SF Queener, V Cody, J Pace, P Torkelson…

Index: Antimicrobial Agents and Chemotherapy, , vol. 57, # 10 p. 4990 - 4998

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Citation Number: 11

Abstract

... Resistance to clinical agents was suggested by these authors to be more likely linked to changes in ... Studies from other sites have failed to find nonsynonomous mutations in DHFR from P. jirovecii, suggesting failure of therapy is not uniquely linked to mutations in DHFR (7–10). ...