Neurotoxicity of free-radical-mediated serotonin neurotoxin in cultured embryonic chick brain neurons

JC Chen, RE Fine, J Squicciarini, L Volicer

Index: Chen, Jin-Chung; Fine, Richard E.; Squicciarini, Joseph; Volicer, Ladislav European Journal of Pharmacology, 1996 , vol. 303, # 1-2 p. 109 - 114

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Citation Number: 4

Abstract

Exposure of serotonin (5-HT) to oxygen-derived free-radical-generating system, xanthine oxidase-hypoxanthine or to a Fenton reaction results in the formation of the neurotoxin, tryptamine-4, 5-dione. In cultured embryonic chick brain neurons, incubation of tryptamine-4, 5-dione or its ethyl carbonate derivative resulted in a dose-dependent neurotoxicity (1–100 μM). The addition of sulfhydryl compound, glutathione at 2 or 10 μM significantly ...