Enzymatic regioselective and complete deacetylation of two arabinonucleosides

…, MA Zinni, M Mohorčič, J Friedrich, AM Iribarren…

Index: Sabaini, Maria B.; Zinni, Maria A.; Mohorcic, Martina; Friedrich, Jozefa; Iribarren, Adolfo M.; Iglesias, Luis E. Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 62, # 3-4 p. 225 - 229

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Citation Number: 8

Abstract

Candida antarctica lipase B (CAL-B)-catalysed regioselective deacetylation of 2′, 3′, 5′- tri-O-acetyl-1-β-d-arabinofuranosyluracil (1) and 2′, 3′, 5′-tri-O-acetyl-9-β-d- arabinofuranosyladenine (2) was studied. The choice of the reaction medium allowed the regioselective formation of products bearing different degree of acetylation: in isopropanol, CAL-B catalysed the formation of the corresponding 2′-O-acetylated arabinonucleosides ...