4-Alkyl-1, 4-dihydropyridine derivatives as specific PAF-acether antagonists

CE Sunkel, M Fau de Casa-Juana…

Index: Sunkel, Carlos E.; Casa-Juana, Miguel Fau de; Santos, Luis; Gomez, M. Mar; Villarroya, Mercedes; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 12 p. 3205 - 3210

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Citation Number: 74

Abstract

A new series of 4-alkyl-1, 4-dihydropyridines (1, 4-DHP) were synthesized and evaluated for their ability to inhibit washed rabbit platelet aggregation induced by PAF-acether (lO- hexadecyl/octadecyl-2-0-acetyl-sn-glycero-3-phosphorylcholine) and to reverse PAF- ...