Pd??EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl??and Alkenyl??Substituted Acetylenes via Microwave??Assisted Sonogashira Type …

J Sedelmeier, SV Ley, H Lange…

Index: Sedelmeier, Joerg; Ley, Steven V.; Lange, Heiko; Baxendale, Ian R. European Journal of Organic Chemistry, 2009 , # 26 p. 4412 - 4420

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Citation Number: 20

Abstract

Abstract We report a rapid microwave-assisted Sonogashira cross-coupling of aryl iodides and bromides with terminal alkynes using Pd-EnCat TM TPP30. Both electron-rich and electron-deficient aryl halides reacted smoothly with a broad variety of terminal alkynes in MeCN at 100–120 C. The coupling products were obtained in good to excellent yields and in high purity. This reaction can be performed under copper-and DMF-free conditions and ...