Selective reduction of amides to amines by boronic acid catalyzed hydrosilylation

Y Li, JA Molina de La Torre, K Grabow…

Index: Li, Yuehui; Molina De La Torre, Jesus A.; Grabow, Kathleen; Bentrup, Ursula; Junge, Kathrin; Zhou, Shaolin; Brueckner, Angelika; Beller, Matthias Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11577 - 11580 Angew. Chem., 2013 , vol. 125, # 44 p. 11791 - 11794,4

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Citation Number: 29

Abstract

Amines constitute important intermediates for the pharmaceutical, agrochemical, and chemical industry. Regarding their preparation, the reduction of carboxamides constitutes a convenient and straightforward synthetic access.[1] Conventionally, amides have been reduced using aluminum or boron hydrides,[2] but these protocols show only limited functionalgroup tolerance. However, for the efficient construction of functionalized ...