e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4, 5-dihydro-6-[4-(1H-imidazol-1-yl) …
I Sircar, RE Weishaar, D Kobylarz…
Index: Sircar; Weishaar; Kobylarz; Moos; Bristol Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1955 - 1962
The structure-activity relationships of a series of 4, 5-dihydro-6-[4-(1H-imidazol-l-yl) phenyl]- 3 (2H)-pyridazinones and related compounds were investigated for the in vivo inhibition of different forms of cyclic nucleotide phosphodiesterase (PDE) isolated from guinea pig ventricular muscle. With few exceptions, these 4, 5-dihydropyridazhones were potent inhibitors of cardiac type I11 phosphodiesterase, which is a low K,, cyclic AMP specific ...
