The optimization of our previous lead compound 1 (AChE IC50= 3.31 μM) through synthesis and pharmacology of a series of novel carbamates is reported. The synthesized compounds were evaluated against mouse brain AChE enzyme using the colorimetric method described by Ellman et al. The three compounds 6a (IC50= 2.57 μM), 6b (IC50= 0.70 μM) and 6i (IC50= 2.56 μM) exhibited potent in vitro AChE inhibitory activities comparable to the drug ...
