Diphenylpropionic acids as new AT1 selective angiotensin II antagonists

…, E Carceller, J García-Rafanell, J Forn

Index: Almansa, Carmen; Gomez, Luis A.; Cavalcanti, Fernando L.; De Arriba, Alberto F.; Rodriguez, Ricardo; Carceller, Elena; Garcia-Rafanell, Julian; Forn, Javier Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2197 - 2206

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Citation Number: 44

Abstract

The synthesis and pharmacological evaluation of a new series of potent AT1 selective diphenylpropionic acid nonpeptide angiotensin II receptor antagonists are reported. The new compounds were evaluated for in vitro AT1 (rat liver) and AT2 (rat adrenal) binding affinity as well as for in vivo inhibition of angiotensin II-induced increase in mean arterial blood pressure in pithed rats. Unsaturation of the diphenylpropionic acids as well as ...