Lipophilicity of some substituted morpholine derivatives synthesized as potential antinociceptive agents

E Rekka, S Retsas, VJ Demopoulos…

Index: Rekka; Retsas; Demopoulos; Kourounakis Archiv der Pharmazie, 1990 , vol. 323, # 1 p. 53 - 56

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Citation Number: 16

Abstract

Abstract Some substituted 2-alkoxy-morpholines have been synthesized as potential antinociceptive agents. These compounds share some structural characteristics of the piperidine analgesics. Their lipophilicity, expressed as log P (octanol-water) and as RM values (from reversed phase thin layer chromatography) was determined. Correlation of these two lipophilicity parameters indicated the classification of the tested compounds into ...